MFF-DT

Across TCGA pan-cancer cohorts, MFF-DT RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MFF-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MFF-DT RNA is repressed in tumor relative to normal tissue. In most cancer types MFF-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and CHOL are the cancer types where MFF-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MFF-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.346	<.001	9	view →
LIHC	All	All	+0.131	<.001	7	view →
CHOL	Male	All	+0.716	<.001	5	view →
KICH	All	All	−0.454	<.001	5	view →
BRCA	Female	All	−0.099	.021	4	view →
BLCA	All	IV	−0.197	.010	2	view →
PRAD	All	All	+0.169	.008	2	view →
LUAD	All	IV	+0.135	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MFF-DT–THCA

Open the THCA breakdown →