MEX3D

Across TCGA cell cohorts, MEX3D mutation is significantly associated with the mutation status of many other genes, with 4,926 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEX3D-associated genes across cancer lineages are CELSR3, NCOR2, and ATP13A1. Each is linked with MEX3D in more than 4 cancer types. Because this analysis shows association rather than direction, both MEX3D-to-partner and partner-to-MEX3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELSR3 grouped by MEX3D-low versus MEX3D-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3D→partner) and Y-score (partner→MEX3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CELSR3 →	+2.101	+3.899	.007	.007	1	5
LARGE_INTESTINE	NCOR2 →	+1.459	+3.862	<.001	<.001	1	5
BLOOD_Leukemia	ATP13A1 →	+3.560	+5.209	<.001	<.001	1	4
SOFT_TISSUE	MET →	+4.502	+5.066	.007	.007	1	4
SOFT_TISSUE	EIF3A →	+5.502	+5.502	.003	.003	1	4
CNS	CHD4 →	+4.044	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,926 associations by consensus.

CELSR3 by MEX3D expression — BLOOD_Leukemia

Explore this box plot interactively →