MEX3C

Across TCGA patient cohorts, MEX3C mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEX3C-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and EGFR. Each is linked with MEX3C in more than 1 cancer types. Because this analysis shows association rather than direction, both MEX3C-to-partner and partner-to-MEX3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MEX3C-low versus MEX3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3C→partner) and Y-score (partner→MEX3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.821	+1.827	<.001	.015	3	2
UCEC	EGFR_pY1068 →	-0.286	-2.700	.001	.006	3	1
UCEC	EGFR →	-0.175	-2.000	.002	.030	3	1
UCEC	eIF4E →	+0.163	+3.013	.035	.018	3	1
UCEC	A-Raf_pS299 →	-0.143	-1.807	.001	.025	3	1
UCEC	ERK2 →	+0.218	+2.000	.002	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by MEX3C expression — UCEC

Explore this box plot interactively →