MEX3C

Across TCGA pan-cancer cohorts, MEX3C RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MEX3C data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MEX3C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MEX3C expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

MESO, KIRP, and LIHC are the cancer types where MEX3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.435	0.678	<.001	105	view →
KIRP	DFS	Median	II,III,IV	0.633	0.882	<.001	49	view →
LIHC	OS	Median	All	0.613	0.768	.001	47	view →
ACC	DFS	Tertile	II,III,IV	0.142	0.709	<.001	45	view →
PAAD	OS	Tertile	II,III,IV	0.339	0.662	<.001	34	view →
UVM	DFS	Quartile	All	0.276	0.846	<.001	32	view →
KIRC	DFS	Median	All	0.716	0.523	.006	31	view →
BLCA	DFS	Tertile	All	0.222	0.594	.001	19	view →
SARC	DFS	Quartile	All	0.206	0.532	.005	19	view →
THYM	DFS	Quartile	All	1.000	0.833	.005	18	view →
BRCA	DFS	Quartile	All	0.967	0.916	.013	16	view →
OV	OS	Quartile	III,IV	0.893	0.788	.037	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MEX3C–MESO (OS)

Open the MESO breakdown →