MEX3B

Across TCGA patient cohorts, MEX3B mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEX3B-associated genes across cancer lineages are Notch1, Annexin_VII, and Cyclin-E2. Each is linked with MEX3B in more than 2 cancer types. Because this analysis shows association rather than direction, both MEX3B-to-partner and partner-to-MEX3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MEX3B-low versus MEX3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3B→partner) and Y-score (partner→MEX3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.130	+1.713	.007	.024	3	3
STAD	Annexin_VII →	-0.217	-3.000	.006	.034	3	2
STAD	Cyclin-E2 →	+0.203	+3.190	.002	.009	3	2
COAD	EGFR_pY1068 →	-0.389	-2.987	.011	.035	3	2
UCEC	Annexin-1 →	+0.501	+1.827	.006	.015	3	2
UCEC	Shc_pY317 →	-0.218	-2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Notch1 by MEX3B expression — UCEC

Explore this box plot interactively →