MEX3B

Across TCGA pan-cancer cohorts, MEX3B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MEX3B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MEX3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MEX3B is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where MEX3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEX3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.685	<.001	12	view →
HNSC	Male	III,IV	+1.188	<.001	11	view →
KIRP	All	II,III,IV	+0.880	<.001	11	view →
COAD	All	All	+0.414	<.001	9	view →
LUAD	Male	II,III,IV	+1.078	<.001	7	view →
LIHC	Female	II,III,IV	+0.710	<.001	7	view →
LUSC	Female	All	+1.642	<.001	6	view →
STAD	Male	II,III,IV	+0.916	.001	6	view →
CHOL	Male	All	+2.110	<.001	3	view →
ESCA	All	All	+0.826	.005	2	view →
KICH	Female	All	−0.478	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MEX3B–KIRC

Open the KIRC breakdown →