METTL7B

Across TCGA patient cohorts, METTL7B mutation is significantly associated with the RNA expression of many other genes, with 518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL7B-associated genes across cancer lineages are RNA5SP100, RNU6-1313P, and MIR4510. Each is linked with METTL7B in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL7B-to-partner and partner-to-METTL7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP100 grouped by METTL7B-low versus METTL7B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL7B→partner) and Y-score (partner→METTL7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP100 →	+0.252	+8.055	<.001	.007	3	2
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	2
SKCM	MIR4510 →	+0.090	+3.784	<.001	.009	3	2
UCEC	TRPC7-AS1 →	+0.244	+2.592	.001	.003	3	2
UCEC	DPP9 →	+0.633	+3.354	<.001	.005	3	2
SKCM	OR7E53P →	+0.033	+2.832	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 518 associations by consensus.

RNA5SP100 by METTL7B expression — BRCA

Explore this box plot interactively →