METTL3

Across TCGA patient cohorts, METTL3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,651 significant associations in total. GBM shows the largest number of these associations.

The most reproducible METTL3-associated genes across cancer lineages are APEX1, DCAF11, and TTC5. Each is linked with METTL3 in more than 6 cancer types. Because this analysis shows association rather than direction, both METTL3-to-partner and partner-to-METTL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL3 versus APEX1 in COAD, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL3→partner) and Y-score (partner→METTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	APEX1 →	+0.554	+0.232	<.001	<.001	3	7
HNSC	DCAF11 →	+0.536	+0.109	<.001	<.001	3	7
LSCC	TTC5 →	+0.534	+0.230	<.001	<.001	3	7
OV	PRMT5 →	+0.580	+0.353	<.001	<.001	3	6
HNSC	DHRS4-AS1 →	+0.494	+0.131	<.001	<.001	3	6
LUAD	HOMEZ →	+0.615	+0.191	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,651 associations by consensus.

METTL3 vs APEX1 — COAD

Explore this scatter interactively →