METTL2A

Across TCGA patient cohorts, METTL2A protein abundance is significantly associated with the RNA expression of many other genes, with 5,924 significant associations in total. GBM shows the largest number of these associations.

The most reproducible METTL2A-associated genes across cancer lineages are DHX40, KPNB1, and MRPS7. Each is linked with METTL2A in more than 3 cancer types. Because this analysis shows association rather than direction, both METTL2A-to-partner and partner-to-METTL2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL2A versus DHX40 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2A→partner) and Y-score (partner→METTL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DHX40 →	+0.538	+0.375	<.001	.002	3	4
BRCA	KPNB1 →	+0.450	+0.652	.003	<.001	3	4
OV	MRPS7 →	+1.158	+0.891	<.001	.001	3	4
OV	NOL11 →	+0.685	+0.548	<.001	.001	3	4
OV	ALYREF →	+0.867	+0.466	.003	.009	3	4
OV	C17orf58 →	+1.086	+0.536	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,924 associations by consensus.

METTL2A vs DHX40 — BRCA

Explore this scatter interactively →