METTL2A

Across TCGA patient cohorts, METTL2A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL2A-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and Heregulin. Each is linked with METTL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL2A-to-partner and partner-to-METTL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by METTL2A-low versus METTL2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2A→partner) and Y-score (partner→METTL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.290	-3.432	.008	.005	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.115	.020	.019	3	1
UCEC	Heregulin →	-0.143	-2.321	.008	.034	3	1
UCEC	ACVRL1 →	-0.157	-3.302	.008	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.223	-2.102	.002	.019	3	1
UCEC	JNK2 →	+0.279	+2.115	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-8 by METTL2A expression — UCEC

Explore this box plot interactively →