METTL24

Across TCGA cell cohorts, METTL24 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,396 significant associations in total. BONE shows the largest number of these associations.

The most reproducible METTL24-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Regulation of cytoplasmic translation, and Mitotic cell cycle phase transition. Each is linked with METTL24 in more than 5 cancer types. Because this analysis shows association rather than direction, both METTL24-to-partner and partner-to-METTL24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by METTL24-low versus METTL24-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL24→partner) and Y-score (partner→METTL24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.101	+0.735	.002	.003	3	5
OVARY	Regulation of cytoplasmic translation →	+0.114	+0.290	<.001	<.001	3	5
LUNG_SCLC	Mitotic cell cycle phase transition →	+0.064	+0.926	<.001	<.001	3	5
LUNG_SCLC	RNA export from nucleus →	+0.062	+0.713	.003	.004	2	6
BONE	DNA replication-dependent chromatin disassembly →	+0.116	+1.512	.003	.001	3	5
LUNG_SCLC	Regulation of cell cycle G1/S phase transition →	+0.055	+0.875	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,396 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by METTL24 expression — LUNG_SCLC

Explore this box plot interactively →