METTL24

Across TCGA pan-cancer cohorts, METTL24 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of METTL24’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where METTL24 RNA is repressed in tumor relative to normal tissue. In most cancer types METTL24 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where METTL24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.644	<.001	11	view →
KICH	Male	All	−1.707	<.001	10	view →
THCA	Male	III,IV	−1.502	<.001	10	view →
BLCA	Male	All	−2.119	<.001	9	view →
READ	All	All	−2.333	<.001	5	view →
STAD	All	All	−1.687	<.001	5	view →
BRCA	Female	II,III,IV	−0.429	<.001	4	view →
CHOL	All	All	+0.968	.002	3	view →
LUAD	All	III,IV	−0.562	<.001	3	view →
PRAD	All	All	−0.812	<.001	2	view →
ESCA	Female	All	−0.943	.005	1	view →
LUSC	Female	III,IV	−0.615	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

METTL24–COAD

Open the COAD breakdown →