METTL22

Across TCGA patient cohorts, METTL22 RNA expression is significantly associated with the mutation status of many other genes, with 10,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL22-associated genes across cancer lineages are TP53, F13B, and XIRP2. Each is linked with METTL22 in more than 6 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by METTL22-low versus METTL22-high in LIHC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TP53 →	+1.640	+0.238	<.001	<.001	3	7
UCEC	F13B →	+2.403	+0.268	<.001	<.001	3	4
UCEC	XIRP2 →	+1.525	+0.149	<.001	.003	3	4
UCEC	FLG →	+1.296	+0.155	<.001	.001	2	5
UCEC	SLIT3 →	+2.868	+0.268	<.001	<.001	3	4
COAD	BRAF →	-3.497	-0.259	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,946 associations by consensus.

TP53 by METTL22 expression — LIHC

Explore this box plot interactively →