METTL22

Across TCGA patient cohorts, METTL22 protein abundance is significantly associated with the RNA expression of many other genes, with 2,220 significant associations in total. GBM shows the largest number of these associations.

The most reproducible METTL22-associated genes across cancer lineages are OR10H1, IGHD6-25, and TXNP1. Each is linked with METTL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL22 versus OR10H1 in LUAD, with a Pearson correlation of -0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR10H1 →	-0.073	-0.352	.003	.007	3	1
LUAD	IGHD6-25 →	-2.475	-0.425	<.001	<.001	3	1
LUAD	TXNP1 →	-0.550	-0.340	.006	.003	3	1
LUAD	MIR4727 →	-1.443	-0.340	.007	.003	3	1
OV	GAPDHP20 →	+0.210	+0.904	.008	.004	3	1
OV	ACSL3-AS1 →	+0.845	+0.904	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

METTL22 vs OR10H1 — LUAD

Explore this scatter interactively →