METTL22

Across TCGA patient cohorts, METTL22 mutation is significantly associated with the RNA expression of many other genes, with 584 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL22-associated genes across cancer lineages are RN7SL408P, RNU6-508P, and RNU6-165P. Each is linked with METTL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL408P grouped by METTL22-low versus METTL22-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL408P →	+0.106	+3.224	<.001	.007	3	2
UCEC	RNU6-508P →	+0.346	+3.716	<.001	.002	3	2
HNSC	RNU6-165P →	+0.280	+5.936	<.001	.001	3	2
LUSC	MTND6P14 →	+0.109	+6.906	<.001	<.001	3	2
LUSC	MIR3194 →	+0.839	+5.337	<.001	.006	3	2
COAD	TXNL4AP1 →	+0.210	+3.951	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 584 associations by consensus.

RN7SL408P by METTL22 expression — SKCM

Explore this box plot interactively →