METTL22

Across TCGA patient cohorts, METTL22 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL22-associated genes across cancer lineages are PRAS40_pT246, Tuberin_pT1462, and Heregulin. Each is linked with METTL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by METTL22-low versus METTL22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.283	+2.183	.001	.035	3	1
UCEC	Tuberin_pT1462 →	+0.321	+2.179	.007	.034	3	1
UCEC	Heregulin →	-0.179	-3.000	.005	.036	2	1
UCEC	Caspase-8 →	-0.284	-3.000	.031	.036	2	1
UCEC	Annexin-1 →	+0.808	+3.321	.003	.010	1	1
UCEC	Caspase-7-cleavedD198 →	+0.712	+3.321	.021	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRAS40_pT246 by METTL22 expression — UCEC

Explore this box plot interactively →