METTL22

Across TCGA cell cohorts, METTL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,972 significant associations in total. BONE shows the largest number of these associations.

The most reproducible METTL22-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, RNA catabolic process, and RNA destabilization. Each is linked with METTL22 in more than 13 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by METTL22-low versus METTL22-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Calcium-independent cell-matrix adhesion →	+0.215	+1.047	.004	<.001	3	14
BONE	RNA catabolic process →	+0.067	+0.789	<.001	<.001	3	14
BLOOD_Myeloma	RNA destabilization →	+0.057	+0.732	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.095	+0.633	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription initiation by RNA polymerase II →	+0.108	+0.848	.002	.001	3	13
SOFT_TISSUE	mRNA catabolic process →	+0.044	+0.569	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,972 associations by consensus.

Calcium-independent cell-matrix adhesion by METTL22 expression — OESOPHAGUS

Explore this box plot interactively →