METTL22

Across TCGA cell cohorts, METTL22 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METTL22-associated genes across cancer lineages are OR9K2, PTPRQ, and SCN1A. Each is linked with METTL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL22-to-partner and partner-to-METTL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9K2 grouped by METTL22-low versus METTL22-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL22→partner) and Y-score (partner→METTL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR9K2 →	+0.013	+5.614	<.001	.002	3	1
LARGE_INTESTINE	PTPRQ →	+0.132	+3.930	<.001	.003	3	1
LARGE_INTESTINE	SCN1A →	+0.198	+4.169	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR9K2 by METTL22 expression — PANCREAS

Explore this box plot interactively →