METTL21C

Across TCGA patient cohorts, METTL21C mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL21C-associated genes across cancer lineages are JNK2, Ku80, and p27_pT198. Each is linked with METTL21C in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL21C-to-partner and partner-to-METTL21C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by METTL21C-low versus METTL21C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL21C→partner) and Y-score (partner→METTL21C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.233	+2.584	.012	.011	3	1
UCEC	Ku80 →	+0.262	+1.887	.017	.031	3	1
UCEC	p27_pT198 →	+0.138	+3.169	.005	.019	3	1
UCEC	PCNA →	+0.213	+2.584	.034	.011	3	1
UCEC	PEA-15_pS116 →	+0.403	+2.584	.013	.011	3	1
UCEC	Rab25 →	-0.338	-2.584	.028	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by METTL21C expression — UCEC

Explore this box plot interactively →