METTL21C

Across TCGA cell cohorts, METTL21C mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METTL21C-associated genes across cancer lineages are Leflunomide, 50869, and 150412. Each is linked with METTL21C in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL21C-to-partner and partner-to-METTL21C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leflunomide grouped by METTL21C-low versus METTL21C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL21C→partner) and Y-score (partner→METTL21C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Leflunomide →	+0.303	+2.769	.017	.040	3	1
LARGE_INTESTINE	50869 →	+0.555	+2.678	.007	.037	3	1
LARGE_INTESTINE	150412 →	+0.403	+2.777	.016	.038	3	1
LARGE_INTESTINE	IWP-2 →	+0.387	+2.893	.002	.034	2	1
LARGE_INTESTINE	SGC-CBP30 →	+0.285	+2.649	.045	.046	2	1
LARGE_INTESTINE	SU11274 →	+0.456	+2.652	.028	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Leflunomide by METTL21C expression — LARGE_INTESTINE

Explore this box plot interactively →