Across TCGA pan-cancer cohorts, METTL21AP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of METTL21AP1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where METTL21AP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types METTL21AP1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, BRCA, and THCA are the cancer types where METTL21AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL21AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.182	.036	2	view →
BRCA	All	IV	−0.169	.003	2	view →
THCA	Male	III,IV	−0.075	.022	2	view →
COAD	All	III,IV	+0.064	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 3 lineages.

Exploration

Same gene, other analysis: METTL21AP1 RNA expression & survival · all METTL21AP1 data types