METTL17

Across TCGA patient cohorts, METTL17 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL17-associated genes across cancer lineages are ATM, eEF2, and EGFR_pY1068. Each is linked with METTL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL17-to-partner and partner-to-METTL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by METTL17-low versus METTL17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL17→partner) and Y-score (partner→METTL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-2.459	.001	.019	3	2
UCEC	eEF2 →	+0.453	+2.906	.002	.001	3	1
UCEC	EGFR_pY1068 →	-0.370	-2.906	<.001	.001	3	1
UCEC	ERK2 →	+0.185	+2.222	.023	.011	3	1
UCEC	FoxM1 →	+0.256	+1.700	.019	.044	3	1
UCEC	INPP4B →	-0.323	-3.321	.018	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by METTL17 expression — UCEC

Explore this box plot interactively →