METTL17

Across TCGA cell cohorts, METTL17 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL17-associated GO terms across cancer lineages are DNA-templated DNA replication maintenance of fidelity, Endothelial to hematopoietic transition, and DNA replication proofreading. Each is linked with METTL17 in more than 15 cancer types. Because this analysis shows association rather than direction, both METTL17-to-partner and partner-to-METTL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication maintenance of fidelity grouped by METTL17-low versus METTL17-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL17→partner) and Y-score (partner→METTL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.099	+0.978	<.001	<.001	3	16
PANCREAS	Endothelial to hematopoietic transition →	+0.106	+0.677	<.001	<.001	3	16
PANCREAS	DNA replication proofreading →	+0.112	+0.439	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.085	+0.753	<.001	<.001	3	15
BLOOD_Myeloma	DNA-templated DNA replication →	+0.123	+0.746	<.001	.008	3	15
SOFT_TISSUE	Constitutive heterochromatin formation →	+0.114	+0.803	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

DNA-templated DNA replication maintenance of fidelity by METTL17 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →