METTL17

Across TCGA cell cohorts, METTL17 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. CNS shows the largest number of these associations.

The most reproducible METTL17-associated genes across cancer lineages are CNPY1, LRRC53, and SELP. Each is linked with METTL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL17-to-partner and partner-to-METTL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNPY1 grouped by METTL17-low versus METTL17-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL17→partner) and Y-score (partner→METTL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CNPY1 →	+0.781	+3.887	.001	.001	3	1
CNS	LRRC53 →	+0.091	+3.201	<.001	.008	3	1
CNS	SELP →	+0.095	+4.096	<.001	.001	3	1
CNS	ACSM2A →	+0.015	+3.887	<.001	.001	3	1
CNS	DGAT2L6 →	+0.632	+3.727	<.001	.005	3	1
CNS	VN1R5 →	+0.068	+3.700	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CNPY1 by METTL17 expression — CNS

Explore this box plot interactively →