METTL15

Across TCGA pan-cancer cohorts, METTL15 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated METTL15 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher METTL15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated METTL15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where METTL15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.842	0.546	.003	31	view →
LUAD	OS	Tertile	All	0.601	0.876	.001	18	view →
LSCC	OS	Median	II,III,IV	1.000	0.886	.025	8	view →
UCEC	DFS	Tertile	All	0.916	1.000	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

METTL15–HNSC (DFS)

Open the HNSC breakdown →