METTL15

Across TCGA patient cohorts, METTL15 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL15-associated genes across cancer lineages are JNK2, PCNA, and Gab2. Each is linked with METTL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL15-to-partner and partner-to-METTL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by METTL15-low versus METTL15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL15→partner) and Y-score (partner→METTL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.262	+2.321	.001	.006	3	2
UCEC	PCNA →	+0.207	+2.459	.020	.019	3	2
UCEC	Gab2 →	+0.333	+2.321	.023	.006	3	1
UCEC	Notch1 →	+0.165	+3.183	.004	.009	3	1
UCEC	P-Cadherin →	-0.125	-3.169	.036	.018	3	1
UCEC	Annexin-1 →	+0.807	+3.479	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by METTL15 expression — UCEC

Explore this box plot interactively →