METTL15

Across TCGA cell cohorts, METTL15 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,884 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL15-associated GO terms across cancer lineages are Mitochondrial small ribosomal subunit assembly, Protein localization to cilium, and Nucleotide-excision repair, DNA gap filling. Each is linked with METTL15 in more than 15 cancer types. Because this analysis shows association rather than direction, both METTL15-to-partner and partner-to-METTL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial small ribosomal subunit assembly grouped by METTL15-low versus METTL15-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL15→partner) and Y-score (partner→METTL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Mitochondrial small ribosomal subunit assembly →	+0.136	+0.907	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to cilium →	+0.054	+0.708	.002	.005	3	9
BLOOD_Lymphoma	Nucleotide-excision repair, DNA gap filling →	+0.086	+0.560	<.001	<.001	3	9
BLOOD_Leukemia	Phosphatidylinositol metabolic process →	+0.047	+0.434	<.001	<.001	3	8
KIDNEY	Regulation of telomere capping →	+0.091	+0.432	.001	<.001	3	8
LARGE_INTESTINE	Golgi organization →	+0.059	+0.635	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,884 associations by consensus.

Mitochondrial small ribosomal subunit assembly by METTL15 expression — BREAST

Explore this box plot interactively →