METTL15

Across TCGA cell cohorts, METTL15 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible METTL15-associated genes across cancer lineages are PYDC1, HES3, and OR4N4. Each is linked with METTL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL15-to-partner and partner-to-METTL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC1 grouped by METTL15-low versus METTL15-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL15→partner) and Y-score (partner→METTL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PYDC1 →	+0.139	+5.087	<.001	.004	3	1
URINARY_TRACT	HES3 →	+0.040	+5.087	<.001	.004	3	1
URINARY_TRACT	OR4N4 →	+0.030	+5.087	<.001	.004	3	1
LARGE_INTESTINE	CPLX4 →	+0.027	+4.392	.001	.004	3	1
LARGE_INTESTINE	FREM3 →	+0.122	+4.054	.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PYDC1 by METTL15 expression — URINARY_TRACT

Explore this box plot interactively →