METRN

Across TCGA cell cohorts, METRN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,981 significant associations in total. BONE shows the largest number of these associations.

The most reproducible METRN-associated GO terms across cancer lineages are Carbohydrate derivative catabolic process, Metanephric proximal tubule development, and Ganglioside metabolic process. Each is linked with METRN in more than 8 cancer types. Because this analysis shows association rather than direction, both METRN-to-partner and partner-to-METRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Carbohydrate derivative catabolic process grouped by METRN-low versus METRN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METRN→partner) and Y-score (partner→METRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Carbohydrate derivative catabolic process →	+0.092	+2.678	<.001	<.001	3	9
SOFT_TISSUE	Metanephric proximal tubule development →	+0.295	+1.759	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Ganglioside metabolic process →	+0.141	+2.188	.004	<.001	3	8
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.202	+2.087	.003	.003	3	8
BONE	Positive regulation of substrate adhesion-dependent cell spreading →	+0.123	+2.048	<.001	<.001	3	8
BONE	Proteoglycan catabolic process →	+0.177	+1.919	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,981 associations by consensus.

Carbohydrate derivative catabolic process by METRN expression — BONE

Explore this box plot interactively →