METRN

Across TCGA pan-cancer cohorts, METRN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated METRN data layer compared with 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher METRN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated METRN expression acts as an unfavorable survival marker, although some lineages such as STAD and OV show a favorable association.

UCS, UVM, and COAD are the cancer types where METRN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	IV	0.302	0.817	.002	82	view →
UVM	OS	Median	III,IV	0.230	0.836	.001	79	view →
COAD	DFS	Median	II,III,IV	0.585	0.729	.001	32	view →
STAD	DFS	Quartile	II,III,IV	0.626	0.291	.003	20	view →
LGG	DFS	Tertile	All	0.736	0.862	<.001	19	view →
ACC	OS	Quartile	IV	0.362	0.754	.010	18	view →
PRAD	DFS	Median	All	0.910	0.955	<.001	18	view →
SARC	DFS	Median	All	0.260	0.502	.002	16	view →
BLCA	DFS	Median	IV	0.242	0.675	<.001	14	view →
KICH	DFS	Quartile	III,IV	0.049	1.000	.017	14	view →
OV	OS	Quartile	II,III,IV	0.904	0.796	.011	14	view →
READ	DFS	Median	III,IV	0.703	0.265	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

METRN–UCS (OS)

Open the UCS breakdown →