METAP1D

Across TCGA pan-cancer cohorts, METAP1D mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of METAP1D’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where METAP1D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types METAP1D is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, HNSC, and CCRCC are the cancer types where METAP1D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METAP1D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−1.044	<.001	7	view →
HNSC	Male	All	−0.308	.011	4	view →
CCRCC	Male	III,IV	+0.229	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

METAP1D–PDAC

Open the PDAC breakdown →