MESTP3

Across TCGA patient cohorts, MESTP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MESTP3-associated GO terms across cancer lineages are Regulation of translation initiation in response to endoplasmic reticulum stress, Centrosome duplication, and Postreplication repair. Each is linked with MESTP3 in more than 19 cancer types. Because this analysis shows association rather than direction, both MESTP3-to-partner and partner-to-MESTP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation initiation in response to endoplasmic reticulum stress grouped by MESTP3-low versus MESTP3-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MESTP3→partner) and Y-score (partner→MESTP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.057	+0.632	<.001	<.001	3	20
ESCA	Centrosome duplication →	+0.076	+0.235	<.001	<.001	3	20
ESCA	Postreplication repair →	+0.061	+0.223	<.001	<.001	3	20
ESCA	Microtubule organizing center organization →	+0.043	+0.175	<.001	<.001	3	20
THYM	Regulation of translation in response to stress →	+0.046	+0.072	<.001	<.001	3	19
THYM	Regulation of translational initiation in response to stress →	+0.054	+0.087	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,807 associations by consensus.

Regulation of translation initiation in response to endoplasmic reticulum stress by MESTP3 expression — TGCT

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