MESTP3

Across TCGA pan-cancer cohorts, MESTP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MESTP3 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MESTP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MESTP3 expression acts as an unfavorable survival marker, although some lineages such as READ and LAML show a favorable association.

KIRC, CESC, and READ are the cancer types where MESTP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.800	0.915	<.001	127	view →
CESC	OS	Median	All	0.816	0.928	.001	60	view →
READ	DFS	Tertile	All	0.930	0.717	<.001	56	view →
ACC	OS	Quartile	All	0.203	0.760	<.001	42	view →
LAML	DFS	Median	All	0.483	0.274	.003	36	view →
LGG	OS	Median	All	0.847	0.934	<.001	19	view →
MESO	DFS	Median	II,III,IV	0.197	0.357	.012	16	view →
TGCT	DFS	Median	All	0.763	0.901	.008	10	view →
OV	OS	Quartile	IV	0.759	0.482	.009	8	view →
STAD	DFS	Quartile	III,IV	0.388	0.615	.029	8	view →
GBM	OS	Median	All	0.344	0.466	.025	6	view →
LUSC	DFS	Quartile	III,IV	0.452	0.993	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MESTP3–KIRC (OS)

Open the KIRC breakdown →