MEST

Across TCGA cell cohorts, MEST mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MEST-associated genes across cancer lineages are OR4F4, OR14A16, and PIGY. Each is linked with MEST in more than 1 cancer types. Because this analysis shows association rather than direction, both MEST-to-partner and partner-to-MEST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by MEST-low versus MEST-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEST→partner) and Y-score (partner→MEST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4F4 →	+0.013	+5.584	<.001	<.001	3	1
BLOOD_Lymphoma	OR14A16 →	+0.013	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	PIGY →	+1.813	+3.736	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR4F4 by MEST expression — BLOOD_Lymphoma

Explore this box plot interactively →