MEPE

Across TCGA patient cohorts, MEPE mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEPE-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and Annexin-1. Each is linked with MEPE in more than 2 cancer types. Because this analysis shows association rather than direction, both MEPE-to-partner and partner-to-MEPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MEPE-low versus MEPE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPE→partner) and Y-score (partner→MEPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.141	+1.906	.038	.016	3	3
UCEC	EGFR_pY1068 →	-0.251	-2.321	.012	.034	3	2
UCEC	Annexin-1 →	+0.658	+2.604	.001	.005	3	2
LUAD	Transglutaminase →	-0.347	-2.321	.028	.035	3	1
UCEC	JNK2 →	+0.225	+2.415	.004	.003	3	1
UCEC	Ku80 →	+0.257	+1.920	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Cyclin-E2 by MEPE expression — UCEC

Explore this box plot interactively →