MEPE

Across TCGA pan-cancer cohorts, MEPE RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MEPE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MEPE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MEPE is over-expressed in tumor.

HNSC, LIHC, and BRCA are the cancer types where MEPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.097	<.001	11	view →
LIHC	All	All	+0.081	<.001	5	view →
BRCA	All	All	+0.136	.013	4	view →
STAD	All	All	+0.042	.011	3	view →
CHOL	All	All	+0.175	.017	1	view →
KICH	All	All	+0.155	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MEPE–HNSC

Open the HNSC breakdown →