MEPE

Across TCGA cell cohorts, MEPE RNA expression is significantly associated with the go_rna of many other GO terms, with 469 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MEPE-associated GO terms across cancer lineages are Branched-chain amino acid transport, COPII-coated vesicle cargo loading, and Regulation of postsynaptic membrane potential. Each is linked with MEPE in more than 3 cancer types. Because this analysis shows association rather than direction, both MEPE-to-partner and partner-to-MEPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branched-chain amino acid transport grouped by MEPE-low versus MEPE-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPE→partner) and Y-score (partner→MEPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Branched-chain amino acid transport →	-0.096	-0.027	.002	.007	3	4
LIVER	COPII-coated vesicle cargo loading →	+0.098	+0.133	.007	.007	3	4
CNS	Regulation of postsynaptic membrane potential →	-0.037	-0.015	.003	.007	3	4
SKIN	Response to steroid hormone →	+0.041	+0.009	.001	.005	3	4
LUNG_SCLC	Regulation of endosome organization →	+0.126	+0.074	<.001	.009	3	4
LUNG_SCLC	Regulation of lipid biosynthetic process →	+0.054	+0.068	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 469 associations by consensus.

Branched-chain amino acid transport by MEPE expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →