MEPE

Across TCGA cell cohorts, MEPE mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEPE-associated genes across cancer lineages are CELA1, SPINK8, and C6orf118. Each is linked with MEPE in more than 1 cancer types. Because this analysis shows association rather than direction, both MEPE-to-partner and partner-to-MEPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA1 grouped by MEPE-low versus MEPE-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPE→partner) and Y-score (partner→MEPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CELA1 →	+0.046	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.344	+5.029	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.105	+4.115	.002	.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.078	+4.887	<.001	.009	3	1
LARGE_INTESTINE	RBMXL2 →	+0.066	+3.554	.006	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CELA1 by MEPE expression — LUNG_SCLC

Explore this box plot interactively →