MEPCE

Across TCGA patient cohorts, MEPCE mutation is significantly associated with the RNA expression of many other genes, with 3,146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEPCE-associated genes across cancer lineages are RNU6-921P, LINC01712, and RPL35AP15. Each is linked with MEPCE in more than 1 cancer types. Because this analysis shows association rather than direction, both MEPCE-to-partner and partner-to-MEPCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-921P grouped by MEPCE-low versus MEPCE-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPCE→partner) and Y-score (partner→MEPCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-921P →	+0.446	+5.421	<.001	.005	3	2
BRCA	LINC01712 →	+0.114	+5.841	.008	.003	3	2
BRCA	RPL35AP15 →	+0.145	+5.020	<.001	.009	3	2
CESC	OR5W2 →	+0.050	+5.969	<.001	.002	3	2
COAD	MIR3128 →	+0.755	+4.596	.003	.001	3	2
SKCM	RNU2-20P →	+0.240	+4.743	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,146 associations by consensus.

RNU6-921P by MEPCE expression — READ

Explore this box plot interactively →