MEPCE

Across TCGA pan-cancer cohorts, MEPCE RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MEPCE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MEPCE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MEPCE is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where MEPCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEPCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.934	<.001	11	view →
COAD	Male	All	+0.691	<.001	10	view →
LIHC	Female	II,III,IV	+1.109	<.001	9	view →
THCA	All	All	−0.356	<.001	9	view →
UCEC	All	All	−0.575	<.001	6	view →
STAD	All	II,III,IV	+0.657	.001	4	view →
CHOL	Male	All	+1.331	<.001	3	view →
LUSC	All	II,III,IV	+0.333	.012	3	view →
READ	All	III,IV	+0.604	.017	2	view →
ESCA	All	All	+0.826	.017	1	view →
LUAD	All	All	−0.231	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MEPCE–HNSC

Open the HNSC breakdown →