MEPCE

Across TCGA patient cohorts, MEPCE mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEPCE-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with MEPCE in more than 1 cancer types. Because this analysis shows association rather than direction, both MEPCE-to-partner and partner-to-MEPCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MEPCE-low versus MEPCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPCE→partner) and Y-score (partner→MEPCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.233	+2.662	.004	<.001	3	2
UCEC	14-3-3_beta →	-0.095	-1.401	.011	.046	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.700	.004	.005	3	1
UCEC	eIF4E →	+0.191	+3.183	.015	.009	3	1
UCEC	ERK2 →	+0.182	+3.321	.011	.009	3	1
UCEC	ACC1 →	+0.283	+2.183	.038	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PCNA by MEPCE expression — UCEC

Explore this box plot interactively →