MEPCE

Across TCGA cell cohorts, MEPCE mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEPCE-associated genes across cancer lineages are IQCF5, ELOA3DP, and C8orf74. Each is linked with MEPCE in more than 1 cancer types. Because this analysis shows association rather than direction, both MEPCE-to-partner and partner-to-MEPCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by MEPCE-low versus MEPCE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEPCE→partner) and Y-score (partner→MEPCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.108	+5.786	<.001	<.001	3	2
LARGE_INTESTINE	ELOA3DP →	+0.022	+2.688	<.001	.002	3	2
LUNG_SCLC	C8orf74 →	+0.102	+4.044	<.001	.009	3	1
BLOOD_Lymphoma	LUZP4 →	+0.069	+4.350	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.107	+4.807	<.001	.003	3	1
BLOOD_Leukemia	GHRHR →	+0.467	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

IQCF5 by MEPCE expression — BLOOD_Leukemia

Explore this box plot interactively →