MEOX2

Across TCGA patient cohorts, MEOX2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEOX2-associated genes across cancer lineages are C-Raf, 4E-BP1_pS65, and eEF2. Each is linked with MEOX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MEOX2-to-partner and partner-to-MEOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MEOX2-low versus MEOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEOX2→partner) and Y-score (partner→MEOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.175	+2.700	.001	.006	3	3
LUAD	4E-BP1_pS65 →	+0.264	+3.334	<.001	.005	3	2
UCEC	eEF2 →	+0.415	+3.169	.003	.018	3	2
UCEC	p21 →	+0.156	+3.321	.038	.010	3	2
UCEC	PKC-delta_pS664 →	-0.115	-2.584	.014	.010	3	2
UCEC	Rictor_pT1135 →	-0.089	-2.459	.027	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

C-Raf by MEOX2 expression — UCEC

Explore this box plot interactively →