MEOX2

Across TCGA pan-cancer cohorts, MEOX2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MEOX2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MEOX2 RNA is repressed in tumor relative to normal tissue. In most cancer types MEOX2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where MEOX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEOX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.515	<.001	11	view →
KICH	Female	All	−1.154	<.001	10	view →
BLCA	Male	IV	−3.300	<.001	8	view →
UCEC	All	III,IV	−3.061	<.001	8	view →
LUSC	Female	All	−2.042	<.001	8	view →
LIHC	Male	All	+0.735	<.001	7	view →
KIRP	All	All	−0.641	<.001	7	view →
BRCA	All	III,IV	−2.868	<.001	6	view →
LUAD	Female	III,IV	−1.638	<.001	6	view →
HNSC	Male	All	−0.976	<.001	6	view →
COAD	Female	II,III,IV	−1.052	<.001	5	view →
KIRC	All	All	+0.491	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MEOX2–THCA

Open the THCA breakdown →