MEMO1

Across TCGA patient cohorts, MEMO1 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEMO1-associated genes across cancer lineages are RN7SKP81, MIR648, and TRGJP1. Each is linked with MEMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEMO1-to-partner and partner-to-MEMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP81 grouped by MEMO1-low versus MEMO1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEMO1→partner) and Y-score (partner→MEMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP81 →	+0.089	+7.924	<.001	.008	3	2
COAD	MIR648 →	+0.704	+4.893	.004	<.001	3	1
COAD	TRGJP1 →	+0.795	+3.754	<.001	.008	3	1
COAD	TRAJ40 →	+0.727	+3.792	.008	.007	3	1
COAD	OR2W2P →	+0.071	+4.537	<.001	.006	3	1
COAD	PSG7 →	+0.084	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

RN7SKP81 by MEMO1 expression — LUSC

Explore this box plot interactively →