MELTF

Across TCGA patient cohorts, MELTF mutation is significantly associated with the RNA expression of many other genes, with 3,588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MELTF-associated genes across cancer lineages are TFIP11, R3HCC1, and GLE1. Each is linked with MELTF in more than 2 cancer types. Because this analysis shows association rather than direction, both MELTF-to-partner and partner-to-MELTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFIP11 grouped by MELTF-low versus MELTF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MELTF→partner) and Y-score (partner→MELTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFIP11 →	+0.364	+1.850	.006	<.001	3	3
UCEC	R3HCC1 →	+0.371	+1.856	.001	.004	3	3
UCEC	GLE1 →	+0.546	+2.050	<.001	<.001	3	3
UCEC	ZWINT →	+0.620	+2.020	<.001	<.001	3	3
BRCA	LINC02563 →	+0.092	+4.027	<.001	.001	3	3
UCEC	FANCC →	+0.360	+1.378	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,588 associations by consensus.

TFIP11 by MELTF expression — UCEC

Explore this box plot interactively →