MELTF

Across TCGA pan-cancer cohorts, MELTF RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MELTF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MELTF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MELTF is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where MELTF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MELTF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.384	<.001	12	view →
LUAD	All	III,IV	+2.027	<.001	11	view →
COAD	Female	All	+2.013	<.001	11	view →
LUSC	Female	All	+3.662	<.001	9	view →
STAD	Male	II,III,IV	+2.457	<.001	9	view →
THCA	Male	All	+1.110	<.001	8	view →
KIRC	Male	II,III,IV	−1.820	<.001	7	view →
KIRP	All	All	−1.430	.001	7	view →
KICH	All	All	−3.036	<.001	6	view →
BRCA	Female	II,III,IV	−0.654	<.001	6	view →
LIHC	All	All	+0.592	.002	5	view →
ESCA	All	All	+2.311	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MELTF–HNSC

Open the HNSC breakdown →