MELTF

Across TCGA cell cohorts, MELTF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,226 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MELTF-associated GO terms across cancer lineages are Positive regulation of extracellular matrix disassembly, Protein localization to plasma membrane, and Regulation of extracellular matrix disassembly. Each is linked with MELTF in more than 11 cancer types. Because this analysis shows association rather than direction, both MELTF-to-partner and partner-to-MELTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of extracellular matrix disassembly grouped by MELTF-low versus MELTF-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MELTF→partner) and Y-score (partner→MELTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of extracellular matrix disassembly →	+0.227	+2.077	<.001	<.001	3	12
PANCREAS	Protein localization to plasma membrane →	+0.047	+1.299	<.001	.001	3	12
SOFT_TISSUE	Regulation of extracellular matrix disassembly →	+0.172	+2.323	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Negative regulation of actin filament polymerization →	+0.120	+1.387	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Response to water →	+0.157	+1.505	.005	.009	3	10
SOFT_TISSUE	Positive regulation of extracellular matrix organization →	+0.137	+2.034	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,226 associations by consensus.

Positive regulation of extracellular matrix disassembly by MELTF expression — BREAST

Explore this box plot interactively →