MELTF

Across TCGA cell cohorts, MELTF mutation is significantly associated with the RNA expression of many other genes, with 463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MELTF-associated genes across cancer lineages are CD40LG, PBK, and MCUB. Each is linked with MELTF in more than 1 cancer types. Because this analysis shows association rather than direction, both MELTF-to-partner and partner-to-MELTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by MELTF-low versus MELTF-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MELTF→partner) and Y-score (partner→MELTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CD40LG →	+0.159	+3.232	<.001	.006	3	2
LARGE_INTESTINE	PBK →	+1.032	+3.502	<.001	.001	3	2
LARGE_INTESTINE	MCUB →	+0.981	+3.169	<.001	.009	3	2
BLOOD_Leukemia	BCL2L12 →	+0.522	+3.411	.007	.003	3	2
BREAST	DEFB125 →	+0.024	+3.727	<.001	.002	3	1
BREAST	OR2B3 →	+0.010	+3.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 463 associations by consensus.

CD40LG by MELTF expression — BREAST

Explore this box plot interactively →