MELK

Across TCGA patient cohorts, MELK protein abundance is significantly associated with the RNA expression of many other genes, with 8,662 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MELK-associated genes across cancer lineages are CENPI, NCAPG, and LMNB1. Each is linked with MELK in more than 4 cancer types. Because this analysis shows association rather than direction, both MELK-to-partner and partner-to-MELK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MELK versus CENPI in LUAD, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MELK→partner) and Y-score (partner→MELK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPI →	+1.703	+1.004	<.001	<.001	3	5
LUAD	NCAPG →	+1.177	+0.863	<.001	<.001	3	5
LUAD	LMNB1 →	+1.575	+0.971	<.001	<.001	3	5
OV	NCAPH →	+1.297	+0.834	<.001	.001	3	5
OV	E2F8 →	+1.497	+0.880	.009	.003	3	5
LUAD	CCNB1 →	+1.298	+0.673	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,662 associations by consensus.

MELK vs CENPI — LUAD

Explore this scatter interactively →